Regulation of hematopoietic stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of hematopoietic stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA0930, CACNB4, and RPS6KA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic stem cell differentiation activity versus KIAA0930 in CCRCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIAA0930 →	-0.377	-0.394	.005	.002	3	4
GBM	CACNB4 →	-0.662	-0.607	<.001	.001	3	4
BRCA	RPS6KA2 →	-0.607	-0.482	<.001	<.001	3	4
OV	ATG7 →	-0.400	-0.450	.002	.009	3	3
HNSC	KRT18P44 →	+0.354	+0.587	.006	.003	3	3
PDAC	IRF2 →	-0.184	-0.345	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902036 vs KIAA0930 — CCRCC

Explore this scatter interactively →