Regulation of hematopoietic stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of hematopoietic stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB4X, EAF1, and ARSD, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic stem cell differentiation activity versus TMSB4X in SOFT_TISSUE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMSB4X →	+5.463	+0.248	.003	.006	2	8
SKIN	EAF1 →	-0.632	-0.224	.007	.004	3	5
URINARY_TRACT	ARSD →	+2.623	+0.289	.005	.003	3	5
SKIN	ACVR2B →	-0.828	-0.227	<.001	.002	3	4
SKIN	VHL →	-0.683	-0.233	<.001	<.001	3	4
OVARY	NAPRT →	+1.484	+0.172	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902036 vs TMSB4X — SOFT_TISSUE

Explore this scatter interactively →