Positive regulation of hematopoietic stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of hematopoietic stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM97, POLR1C, and CCDC138, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hematopoietic stem cell proliferation activity versus TMEM97 in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM97 →	+0.932	+1.130	<.001	<.001	3	7
BRCA	POLR1C →	+0.497	+0.796	<.001	<.001	3	7
HNSC	CCDC138 →	+0.650	+0.524	.001	.003	3	6
GBM	LIN9 →	+0.682	+0.776	<.001	<.001	3	6
LSCC	HINT2 →	+0.243	+0.959	<.001	<.001	3	6
GBM	SKA1 →	+0.796	+0.826	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902035 vs TMEM97 — LSCC

Explore this scatter interactively →