Regulation of hematopoietic stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of hematopoietic stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCOR1, NCOR1_S224, and SERPINH1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic stem cell proliferation activity versus NCOR1 in BRCA (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCOR1 →	-0.245	-0.045	<.001	<.001	3	7
BRCA	NCOR1_S224 →	-0.460	-0.061	<.001	<.001	3	7
GBM	SERPINH1 →	+0.635	+0.093	<.001	<.001	3	6
GBM	CRTAP →	+0.443	+0.088	<.001	<.001	3	6
GBM	DCN →	+0.789	+0.066	<.001	<.001	3	6
GBM	F13A1 →	+1.036	+0.067	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902033 vs NCOR1 — BRCA

Explore this scatter interactively →