Regulation of hematopoietic stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of hematopoietic stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00339, CCNB1IP1, and POLR1E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic stem cell proliferation activity versus LINC00339 in PDAC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LINC00339 →	+0.255	+0.612	.002	.009	3	4
UCEC	CCNB1IP1 →	+0.739	+0.672	.005	<.001	3	4
UCEC	POLR1E →	+0.486	+0.485	.006	<.001	3	4
UCEC	DDOST →	+0.572	+0.375	.008	.006	3	4
BRCA	SUV39H2 →	+0.586	+0.894	<.001	<.001	3	4
LSCC	XPO5 →	+0.478	+0.708	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902033 vs LINC00339 — PDAC

Explore this scatter interactively →