Regulation of hematopoietic stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of hematopoietic stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC2, HERC5, and OTUD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic stem cell proliferation activity versus EXOSC2 in BLOOD_Myeloma (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EXOSC2 →	+0.752	+1.727	<.001	.001	3	5
BLOOD_Myeloma	HERC5 →	+3.022	+1.727	<.001	.001	3	5
BLOOD_Myeloma	OTUD1 →	+1.170	+2.011	.005	<.001	2	6
BLOOD_Myeloma	OLA1 →	+0.908	+1.727	.001	.001	3	4
BLOOD_Myeloma	CENPE →	+1.303	+2.005	.006	<.001	3	4
BLOOD_Myeloma	ACOT7 →	+1.975	+1.727	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902033 vs EXOSC2 — BLOOD_Myeloma

Explore this scatter interactively →