Regulation of NADP metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of NADP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ME2, LCP1, and AASS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NADP metabolic process activity versus ME2 in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ME2 →	+0.346	+0.067	<.001	<.001	3	7
GBM	LCP1 →	+0.539	+0.066	<.001	<.001	3	6
GBM	AASS →	-0.362	-0.051	<.001	.002	3	5
GBM	LCP2 →	+0.566	+0.074	<.001	<.001	3	5
CCRCC	LMNB2 →	-0.236	-0.061	.008	.003	2	6
LSCC	TP53_S315 →	+1.323	+0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902031 vs ME2 — LSCC

Explore this scatter interactively →