Regulation of NADP metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of NADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX6C, NANOGP2, and DMAC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NADP metabolic process activity versus COX6C in BRCA (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COX6C →	-0.985	-0.171	<.001	<.001	3	3
LUAD	NANOGP2 →	+0.605	+0.136	.006	<.001	3	3
BRCA	DMAC2 →	-0.361	-0.139	.001	.002	3	3
BRCA	LANCL1 →	-0.416	-0.154	.002	.002	3	3
BRCA	BCL2 →	-0.953	-0.152	.001	.001	3	3
HNSC	TP53 →	+0.810	+0.217	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902031 vs COX6C — BRCA

Explore this scatter interactively →