L-lysine transport

Across TCGA patient cohorts, RNA activity of the L-lysine transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHLDB2, MSN, and BAK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-lysine transport activity versus PHLDB2 in COAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PHLDB2 →	-0.339	-0.045	.004	<.001	3	4
BRCA	MSN →	-0.222	-0.032	.003	.004	3	4
COAD	BAK1 →	-0.276	-0.065	.007	<.001	3	4
HNSC	PPP1R18_S145 →	-0.480	-0.065	<.001	.007	3	4
GBM	L2HGDH →	+0.165	+0.047	.008	<.001	3	4
OV	ZNF827_S518 →	-0.704	-0.062	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902022 vs PHLDB2 — COAD

Explore this scatter interactively →