L-lysine transport

Across TCGA patient cohorts, RNA activity of the L-lysine transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASGRP3, CD1D, and GIMAP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-lysine transport activity versus RASGRP3 in HNSC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RASGRP3 →	-0.546	-0.812	<.001	<.001	3	5
LSCC	CD1D →	-0.574	-0.893	<.001	<.001	3	5
LSCC	GIMAP4 →	-0.634	-0.775	.003	.005	2	6
PDAC	CDC42P4 →	-0.311	-0.518	.001	.007	3	5
HNSC	NAP1L3 →	-0.522	-0.575	<.001	<.001	3	4
CCRCC	IFNAR2 →	-0.395	-0.179	.002	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902022 vs RASGRP3 — HNSC

Explore this scatter interactively →