Negative regulation of cilium assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of cilium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTF3C4, RSF1_S397, and MCM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cilium assembly activity versus GTF3C4 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GTF3C4 →	+0.278	+0.077	<.001	.001	3	7
LUAD	RSF1_S397 →	+0.712	+0.041	<.001	<.001	3	6
GBM	MCM2 →	+0.595	+0.052	<.001	<.001	3	6
GBM	MCM5 →	+0.534	+0.046	.002	.002	3	6
LSCC	NASP →	+0.604	+0.072	<.001	<.001	3	6
LUAD	SMC2 →	+0.571	+0.053	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902018 vs GTF3C4 — HNSC

Explore this scatter interactively →