Negative regulation of cilium assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPATCH2L, FBXW2, and KLC1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cilium assembly activity versus GPATCH2L in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPATCH2L →	+1.126	+0.076	<.001	<.001	3	18
SOFT_TISSUE	FBXW2 →	+1.163	+0.079	<.001	<.001	3	18
URINARY_TRACT	KLC1 →	+1.058	+0.086	.002	<.001	3	18
LIVER	EVI5L →	+1.351	+0.089	.003	<.001	3	18
URINARY_TRACT	FKBP15 →	+0.967	+0.085	.001	.001	3	17
LUNG_NSCLC_LUSC	MAP4K5 →	+0.994	+0.092	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902018 vs GPATCH2L — UPPER_AERODIGESTIVE_TRACT

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