Negative regulation of cilium assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMA1, RHOA, and SUCLG2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cilium assembly activity versus LIMA1 in KIDNEY (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LIMA1 →	+1.558	+0.237	.002	.006	3	7
SKIN	RHOA →	+0.495	+0.145	.001	.008	3	5
OVARY	SUCLG2 →	+0.770	+0.244	.009	.005	2	6
SKIN	STAM →	+0.756	+0.222	.001	.003	3	4
SKIN	ATP5MG →	-0.630	-0.204	.003	.001	3	4
PANCREAS	HDLBP →	+0.635	+0.242	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902018 vs LIMA1 — KIDNEY

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