Regulation of cilium assembly

Across TCGA patient cohorts, RNA activity of the Regulation of cilium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, IFT22, and MAP1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium assembly activity versus VCAN in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VCAN →	+0.687	+0.028	.004	.001	3	7
BRCA	IFT22 →	+0.258	+0.023	.003	.002	3	7
OV	MAP1A →	+0.349	+0.034	.001	.002	3	7
BRCA	MRPL51 →	-0.386	-0.030	<.001	<.001	3	7
BRCA	RPL3 →	-0.422	-0.038	<.001	<.001	3	6
GBM	RPL4 →	-0.400	-0.042	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902017 vs VCAN — OV

Explore this scatter interactively →