Regulation of cilium assembly

Across TCGA patient cohorts, RNA activity of the Regulation of cilium assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYGB, SPEM1, and AP2A1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium assembly activity versus PYGB in CCRCC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PYGB →	-0.309	-0.432	.002	<.001	3	2
CCRCC	SPEM1 →	-0.043	-0.469	.007	.005	3	2
CCRCC	AP2A1 →	-0.293	-0.397	.007	.004	3	2
HNSC	DNAJA3 →	-0.603	-0.662	.009	.009	3	1
HNSC	TASOR2 →	-0.590	-0.644	.004	.005	3	1
HNSC	GNA13 →	-0.555	-0.611	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902017 vs PYGB — CCRCC

Explore this scatter interactively →