Positive regulation of amyloid-beta formation

Across TCGA patient cohorts, RNA activity of the Positive regulation of amyloid-beta formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPS5, and RRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid-beta formation activity versus RPL5 in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.222	-0.064	<.001	<.001	3	6
BRCA	RPS5 →	-0.237	-0.050	<.001	<.001	3	6
OV	RRP1 →	-0.362	-0.053	.006	.003	3	6
UCEC	SRPK1_S311 →	-0.379	-0.076	.002	<.001	3	6
HNSC	RSL1D1_S443 →	-0.566	-0.052	<.001	.003	3	6
COAD	GSPT1 →	-0.222	-0.027	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902004 vs RPL5 — GBM

Explore this scatter interactively →