Positive regulation of amyloid-beta formation

Across TCGA patient cohorts, RNA activity of the Positive regulation of amyloid-beta formation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOC3, LINC01424, and PBX4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid-beta formation activity versus THOC3 in OV (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THOC3 →	-0.900	-0.849	<.001	<.001	3	3
UCEC	LINC01424 →	-0.450	-0.855	.002	.002	3	3
LUAD	PBX4 →	+0.295	+0.285	.009	.008	3	3
HNSC	ZNF530 →	+0.430	+0.389	.001	.003	3	2
HNSC	EIF4ENIF1 →	+0.342	+0.435	.003	.004	2	3
HNSC	ZNF551 →	+0.575	+0.427	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902004 vs THOC3 — OV

Explore this scatter interactively →