Positive regulation of amyloid-beta formation

Across TCGA cell cohorts, RNA activity of the Positive regulation of amyloid-beta formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCL3, SIRPA, and SEMA6B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid-beta formation activity versus PDCL3 in LUNG_NSCLC_LUAD (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PDCL3 →	-0.550	-0.915	.004	.003	3	4
OVARY	SIRPA →	-1.205	-0.880	.008	.002	3	4
OESOPHAGUS	SEMA6B →	-1.871	-1.131	.009	.001	3	4
BLOOD_Leukemia	MFSD2A →	-1.634	-0.792	<.001	.002	3	4
BONE	PCYOX1 →	+1.314	+1.559	.007	.001	3	3
STOMACH	RPS2 →	-1.024	-1.177	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902004 vs PDCL3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →