Fatty acid transmembrane transport

Across TCGA patient cohorts, RNA activity of the Fatty acid transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD36, ACSL1, and TMX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid transmembrane transport activity versus CD36 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD36 →	+1.010	+0.042	.001	<.001	3	8
OV	ACSL1 →	+0.675	+0.052	<.001	<.001	3	7
BRCA	TMX2 →	-0.650	-0.037	<.001	<.001	3	7
GBM	S100A4 →	+0.792	+0.075	<.001	<.001	3	6
LSCC	SSH1_S897 →	+0.410	+0.049	<.001	.001	3	6
GBM	TK2 →	+0.321	+0.054	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902001 vs CD36 — BRCA

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