Fatty acid transmembrane transport

Across TCGA patient cohorts, RNA activity of the Fatty acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, CARS2, and ANKRD10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid transmembrane transport activity versus IRS2 in BRCA (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRS2 →	+1.081	+0.267	<.001	.006	3	9
LSCC	CARS2 →	+0.552	+0.279	<.001	<.001	3	6
LSCC	ANKRD10 →	+0.768	+0.335	<.001	<.001	3	6
LSCC	CUL4A →	+0.772	+0.227	.001	.004	3	5
LSCC	NAXD →	+0.511	+0.248	.001	.002	3	5
LSCC	MYO16-AS1 →	+1.191	+0.300	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902001 vs IRS2 — BRCA

Explore this scatter interactively →