Negative regulation of meiotic cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of meiotic cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP85L, BLOC1S6, and SEC23IP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP85L grouped by Negative regulation of meiotic cell cycle phase transition-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CEP85L →	-0.794	-1.380	.001	.008	3	4
PANCREAS	BLOC1S6 →	-0.580	-0.234	.003	.007	2	4
LIVER	SEC23IP →	-0.881	-1.989	.008	.004	3	3
OESOPHAGUS	SLC35D1 →	-0.482	-0.146	<.001	.004	3	3
SOFT_TISSUE	YOD1 →	-0.981	-0.227	.003	.009	3	3
OESOPHAGUS	PPP4R3B →	-0.646	-0.209	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP85L by Negative regulation of meiotic cell cycle phase transition activity — BONE

Explore this box plot interactively →