Negative regulation of meiotic cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of meiotic cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK35, ZCCHC3, and PANK2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of meiotic cell cycle phase transition activity versus STK35 in BONE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	STK35 →	+1.138	+0.155	<.001	.002	2	19
STOMACH	ZCCHC3 →	+0.882	+0.086	.001	.002	3	14
STOMACH	PANK2 →	+0.750	+0.104	.004	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	PRPF38A →	+0.802	+0.076	<.001	.009	3	11
BLOOD_Lymphoma	SASS6 →	+1.128	+0.066	<.001	<.001	3	11
BONE	RAD54L →	+1.063	+0.111	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901994 vs STK35 — BONE

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