Regulation of meiotic cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Regulation of meiotic cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAR1A, INPP5B, and ITPR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of meiotic cell cycle phase transition activity versus SAR1A in PANCREAS (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SAR1A →	+1.126	+1.932	<.001	.008	3	5
BLOOD_Myeloma	INPP5B →	+1.609	+1.876	<.001	.002	3	5
LUNG_SCLC	ITPR2 →	+1.638	+0.848	.001	.007	3	4
LUNG_SCLC	PIK3C2B →	+1.684	+1.040	<.001	<.001	3	4
BLOOD_Myeloma	SNX4 →	+1.529	+1.924	.003	.001	3	4
BLOOD_Myeloma	TOR1AIP1 →	+1.717	+1.591	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901993 vs SAR1A — PANCREAS

Explore this scatter interactively →