Positive regulation of mitotic cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPS8L1, CDCA7, and IFIH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPS8L1 grouped by Positive regulation of mitotic cell cycle phase transition-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EPS8L1 →	+3.587	+0.272	.002	.005	3	6
LARGE_INTESTINE	CDCA7 →	-1.166	-0.181	<.001	.002	3	5
URINARY_TRACT	IFIH1 →	+2.315	+0.261	.002	<.001	3	5
PANCREAS	USP13 →	-0.757	-0.195	.003	.001	3	5
URINARY_TRACT	NEDD9 →	+3.496	+0.228	<.001	<.001	3	5
URINARY_TRACT	ELF1 →	+1.480	+0.277	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPS8L1 by Positive regulation of mitotic cell cycle phase transition activity — PANCREAS

Explore this box plot interactively →