Positive regulation of mitotic cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF168, AASDHPPT, and BICD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cell cycle phase transition activity versus RNF168 in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RNF168 →	+1.180	+0.425	<.001	.004	3	6
LARGE_INTESTINE	AASDHPPT →	+0.619	+0.840	.005	.001	3	4
SOFT_TISSUE	BICD2 →	+0.860	+1.250	.001	.003	3	4
LARGE_INTESTINE	S1PR2 →	+0.585	+0.922	.009	<.001	3	4
BLOOD_Leukemia	DOCK6 →	-1.497	-0.346	.006	.009	3	4
BREAST	RAD51 →	+0.661	+0.576	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901992 vs RNF168 — BLOOD_Leukemia

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