Positive regulation of cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVL, SQOR, and CAND1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle phase transition activity versus EVL in OESOPHAGUS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EVL →	+1.825	+0.173	.004	<.001	3	6
SOFT_TISSUE	SQOR →	-3.632	-0.269	<.001	.001	3	6
BLOOD_Leukemia	CAND1 →	+0.826	+0.158	<.001	.001	3	6
LUNG_SCLC	CNIH2 →	+2.194	+0.240	<.001	<.001	3	6
BLOOD_Lymphoma	ARF4 →	-0.724	-0.155	<.001	<.001	3	5
BLOOD_Leukemia	TCF20 →	+0.734	+0.204	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901989 vs EVL — OESOPHAGUS

Explore this scatter interactively →