Positive regulation of protein acetylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein acetylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRELP, SHISAL1, and NEIL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein acetylation activity versus PRELP in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRELP →	-1.031	-0.563	.004	.001	3	6
GBM	SHISAL1 →	-0.975	-0.886	<.001	<.001	3	6
BRCA	NEIL3 →	+0.878	+0.794	<.001	<.001	3	6
BRCA	C7 →	-1.233	-0.492	.001	.008	3	6
BRCA	ITGBL1 →	-1.169	-0.691	<.001	.001	3	6
OV	IRAG1 →	-1.025	-0.234	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901985 vs PRELP — BRCA

Explore this scatter interactively →