Positive regulation of protein acetylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein acetylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCE1, CARS1, and STARD5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCE1 grouped by Positive regulation of protein acetylation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RCE1 →	+0.611	+0.226	.005	.006	3	3
LUNG_SCLC	CARS1 →	+0.899	+0.265	.003	.005	3	3
LUNG_NSCLC_LUAD	STARD5 →	-0.627	-0.203	.004	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	IL18R1 →	-0.953	-0.266	.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	NDUFA8 →	-1.100	-0.313	.009	.008	3	2
UPPER_AERODIGESTIVE_TRACT	PCTP →	-0.977	-0.324	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCE1 by Positive regulation of protein acetylation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →