Regulation of protein acetylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein acetylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCN2, MRPL36, and DNM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCN2 grouped by Regulation of protein acetylation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TCN2 →	-1.994	-1.449	.002	<.001	3	4
URINARY_TRACT	MRPL36 →	-0.825	-2.096	.002	<.001	3	4
BREAST	DNM1 →	+1.376	+0.704	.001	.005	3	3
BREAST	SUB1 →	-0.790	-0.982	.001	.003	3	3
BLOOD_Leukemia	ELOVL3 →	+1.185	+1.050	.004	.005	3	3
BREAST	RILP →	+0.972	+0.890	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCN2 by Regulation of protein acetylation activity — OVARY

Explore this box plot interactively →