Positive regulation of cell cycle checkpoint

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK1, GINS1, and NCAPG, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle checkpoint activity versus VRK1 in ACC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	VRK1 →	+1.154	+0.088	<.001	<.001	3	33
LIHC	GINS1 →	+1.787	+0.077	<.001	<.001	3	33
ACC	NCAPG →	+2.104	+0.091	<.001	<.001	3	33
UVM	DDX55 →	+1.067	+0.039	<.001	<.001	3	33
ACC	HELLS →	+1.391	+0.077	<.001	<.001	3	33
DLBC	TMPO →	+1.328	+0.072	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901978 vs VRK1 — ACC

Explore this scatter interactively →