Positive regulation of cell cycle checkpoint

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCI, ASPM, and E2F2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle checkpoint activity versus FANCI in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FANCI →	+0.810	+0.712	.001	.005	3	7
GBM	ASPM →	+0.961	+0.617	<.001	<.001	3	7
GBM	E2F2 →	+0.986	+1.085	<.001	<.001	3	7
OV	CDCA8 →	+1.004	+0.735	<.001	<.001	3	6
BRCA	CDC25A →	+0.933	+0.795	<.001	<.001	3	6
OV	LRR1 →	+0.583	+0.756	.007	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901978 vs FANCI — GBM

Explore this scatter interactively →