Positive regulation of cell cycle checkpoint

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXPH5, MAP3K5, and TBCE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXPH5 grouped by Positive regulation of cell cycle checkpoint-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EXPH5 →	+2.596	+0.190	<.001	<.001	3	5
BLOOD_Lymphoma	MAP3K5 →	+2.406	+0.308	<.001	.001	3	4
KIDNEY	TBCE →	-0.596	-0.224	.001	<.001	3	4
BONE	CBR3 →	-2.429	-0.282	<.001	.003	3	4
SOFT_TISSUE	NANS →	-0.720	-0.219	<.001	<.001	3	4
STOMACH	SPATA6L →	+1.682	+0.183	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXPH5 by Positive regulation of cell cycle checkpoint activity — STOMACH

Explore this box plot interactively →