Negative regulation of cell cycle checkpoint

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV1, ANTXR2, and RAB31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell cycle checkpoint activity versus CAV1 in HNSC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CAV1 →	-1.044	-0.118	.002	.004	3	4
LSCC	ANTXR2 →	-0.428	-0.145	.004	<.001	3	4
LSCC	RAB31 →	-0.536	-0.151	<.001	<.001	3	4
LSCC	PEF1-AS1 →	-0.313	-0.161	.002	.004	3	4
LSCC	TLL1 →	-0.610	-0.161	.006	.004	3	4
PDAC	VTCN1 →	+0.810	+0.151	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901977 vs CAV1 — HNSC

Explore this scatter interactively →