Negative regulation of cell cycle checkpoint

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2N1, TUBB2B, and NFATC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell cycle checkpoint activity versus CAMK2N1 in OVARY (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CAMK2N1 →	-2.333	-0.890	.001	.006	3	4
BLOOD_Lymphoma	TUBB2B →	+2.941	+0.944	.005	.007	2	4
BLOOD_Lymphoma	NFATC3 →	+0.968	+1.330	.002	<.001	3	3
STOMACH	COPS2 →	-0.650	-1.294	.001	.008	3	3
KIDNEY	PHAX →	-0.668	-1.430	<.001	.009	3	3
LUNG_SCLC	GTPBP10 →	-0.505	-1.037	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901977 vs CAMK2N1 — OVARY

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