Regulation of cell cycle checkpoint

Across TCGA patient cohorts, RNA activity of the Regulation of cell cycle checkpoint pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP1B_S513, UFD1_S247, and CHAF1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell cycle checkpoint activity versus RRP1B_S513 in BRCA (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RRP1B_S513 →	+1.441	+0.491	<.001	.003	3	5
BRCA	UFD1_S247 →	+0.994	+0.458	<.001	<.001	3	5
LSCC	CHAF1A →	+0.431	+0.342	<.001	<.001	3	5
GBM	CHAF1B →	+0.720	+0.603	<.001	<.001	3	5
GBM	CNOT11 →	+0.222	+0.633	<.001	<.001	3	5
BRCA	DGKQ →	-0.409	-0.431	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901976 vs RRP1B_S513 — BRCA

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