Regulation of cell cycle checkpoint

Across TCGA cell cohorts, RNA activity of the Regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC19, YTHDC2, and MND1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC19 grouped by Regulation of cell cycle checkpoint-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNAJC19 →	-0.562	-0.166	.005	.001	3	4
OVARY	YTHDC2 →	-0.836	-0.090	.005	.002	3	4
LARGE_INTESTINE	MND1 →	-1.000	-0.160	.003	.001	3	4
LUNG_NSCLC_LUSC	SLC49A4 →	+0.730	+0.113	.002	<.001	3	4
BLOOD_Lymphoma	SOD1 →	-0.726	-0.282	.007	.004	3	4
BREAST	JOSD2 →	+0.801	+0.131	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC19 by Regulation of cell cycle checkpoint activity — BLOOD_Myeloma

Explore this box plot interactively →