Regulation of cell cycle checkpoint

Across TCGA cell cohorts, RNA activity of the Regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKP2, CDKN2C, and TMEM131L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell cycle checkpoint activity versus PKP2 in STOMACH (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PKP2 →	-2.852	-0.947	.002	.006	3	5
BONE	CDKN2C →	+1.663	+0.295	.001	.003	3	4
SOFT_TISSUE	TMEM131L →	+1.117	+0.263	.002	<.001	3	4
STOMACH	P3H1 →	+1.565	+0.653	.008	.004	3	4
STOMACH	DENND5A →	+3.704	+1.124	.002	.001	3	4
OVARY	OVOL2 →	-2.164	-0.588	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901976 vs PKP2 — STOMACH

Explore this scatter interactively →