Regulation of relaxation of cardiac muscle

Across TCGA patient cohorts, RNA activity of the Regulation of relaxation of cardiac muscle pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, TAGLN, and CNRIP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of relaxation of cardiac muscle activity versus FERMT2 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FERMT2 →	+0.536	+0.083	<.001	<.001	3	9
OV	TAGLN →	+0.795	+0.063	<.001	<.001	3	8
LSCC	CNRIP1 →	+0.516	+0.149	<.001	<.001	3	8
UCEC	CORO2B →	+0.594	+0.082	.002	.004	3	8
OV	HSPG2 →	+0.594	+0.103	.001	<.001	3	8
UCEC	KANK2_S540 →	+0.554	+0.117	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901897 vs FERMT2 — UCEC

Explore this scatter interactively →