Regulation of relaxation of cardiac muscle

Across TCGA cell cohorts, RNA activity of the Regulation of relaxation of cardiac muscle pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP1, TMEM104, and SH2D3A, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP1 grouped by Regulation of relaxation of cardiac muscle-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GTPBP1 →	+0.625	+0.212	.002	.008	2	1
LUNG_SCLC	TMEM104 →	+0.080	+0.212	.007	.008	2	1
LUNG_SCLC	SH2D3A →	+0.280	+0.212	.008	.008	2	1
LUNG_SCLC	ARMCX5 →	+0.185	+0.212	.003	.008	2	1
LUNG_SCLC	AAR2 →	+0.454	+0.212	.003	.008	2	1
LUNG_SCLC	POLR1E →	+0.435	+0.212	.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP1 by Regulation of relaxation of cardiac muscle activity — LUNG_SCLC

Explore this box plot interactively →