Regulation of relaxation of cardiac muscle

Across TCGA cell cohorts, RNA activity of the Regulation of relaxation of cardiac muscle pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are CRT0160829, MK-1775, and AZ20, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRT0160829 grouped by Regulation of relaxation of cardiac muscle-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CRT0160829 →	-1.111	-0.850	<.001	.037	3	2
LUNG_SCLC	MK-1775 →	-0.679	-0.867	.004	.038	3	1
LUNG_SCLC	AZ20 →	-0.809	-0.866	.004	.033	3	1
LUNG_SCLC	PCI-34051 →	-0.478	-0.750	.009	.024	3	1
LUNG_SCLC	BMS-754807 →	-1.275	-1.056	.020	.023	3	1
LUNG_SCLC	PFI-1 →	-0.700	-1.148	.003	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRT0160829 by Regulation of relaxation of cardiac muscle activity — LUNG_SCLC

Explore this box plot interactively →