Regulation of ATPase-coupled calcium transmembrane transporter activity

Across TCGA patient cohorts, RNA activity of the Regulation of ATPase-coupled calcium transmembrane transporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLMAP, ENTPD1, and FLNA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATPase-coupled calcium transmembrane transporter activity activity versus SLMAP in COAD (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLMAP →	+0.545	+0.101	<.001	<.001	3	6
COAD	ENTPD1 →	+0.255	+0.070	.001	.002	3	6
UCEC	FLNA →	+1.009	+0.184	<.001	<.001	3	6
GBM	ARHGAP10 →	+0.300	+0.116	.001	<.001	3	6
GBM	FHOD1 →	+0.390	+0.117	.001	<.001	3	5
UCEC	CALD1 →	+1.247	+0.163	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901894 vs SLMAP — COAD

Explore this scatter interactively →