Regulation of ATPase-coupled calcium transmembrane transporter activity

Across TCGA patient cohorts, RNA activity of the Regulation of ATPase-coupled calcium transmembrane transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A3, ABCG4, and SLIT3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATPase-coupled calcium transmembrane transporter activity activity versus SLC30A3 in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC30A3 →	+0.718	+0.890	.004	<.001	3	3
CCRCC	ABCG4 →	+0.092	+1.105	.002	.001	3	3
CCRCC	SLIT3 →	+1.387	+1.377	<.001	<.001	3	3
PDAC	PPM1N →	-0.722	-0.707	<.001	.008	3	3
OV	CXCR1 →	+0.487	+0.189	.007	.006	3	3
LUAD	NRON →	+0.759	+0.748	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901894 vs SLC30A3 — GBM

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