Regulation of cell junction assembly

Across TCGA cell cohorts, RNA activity of the Regulation of cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV2, PRR22, and SDC4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell junction assembly activity versus CAV2 in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CAV2 →	+2.543	+0.218	.002	<.001	3	7
LIVER	PRR22 →	-1.255	-0.248	.001	.001	3	6
LARGE_INTESTINE	SDC4 →	+1.958	+0.238	<.001	<.001	3	6
STOMACH	OSER1 →	+1.152	+0.223	<.001	<.001	3	6
STOMACH	DNTTIP1 →	+1.142	+0.232	.001	<.001	3	6
STOMACH	TBC1D2 →	+1.452	+0.251	.005	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901888 vs CAV2 — OVARY

Explore this scatter interactively →