Positive regulation of protein depolymerization

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEYL, PTP4A2P2, and FHL5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein depolymerization activity versus HEYL in CCRCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HEYL →	+0.727	+0.942	<.001	<.001	3	6
CCRCC	PTP4A2P2 →	+0.976	+1.233	<.001	<.001	3	6
CCRCC	FHL5 →	+0.993	+1.011	<.001	<.001	3	6
CCRCC	CYGB →	+0.663	+0.929	<.001	<.001	3	6
HNSC	NES →	+1.240	+1.103	<.001	<.001	3	6
CCRCC	FRMD3 →	+0.790	+0.804	.003	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901881 vs HEYL — CCRCC

Explore this scatter interactively →