Positive regulation of protein depolymerization

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR87, CDC42BPG, and IRS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR87 grouped by Positive regulation of protein depolymerization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GPR87 →	+5.476	+2.135	.004	<.001	3	4
URINARY_TRACT	CDC42BPG →	+3.960	+1.907	<.001	.001	3	4
LIVER	IRS2 →	-2.126	-1.490	<.001	.001	3	3
PANCREAS	CPVL →	+3.004	+1.163	.001	.001	2	4
BLOOD_Lymphoma	AGR2 →	+0.743	+0.633	.009	.002	3	3
LARGE_INTESTINE	ADH5 →	+1.013	+1.094	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR87 by Positive regulation of protein depolymerization activity — URINARY_TRACT

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