Regulation of protein depolymerization

Across TCGA cell cohorts, RNA activity of the Regulation of protein depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGOLN2, CARD19, and CAPZA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein depolymerization activity versus TGOLN2 in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TGOLN2 →	+1.747	+0.650	.002	.004	3	5
OVARY	CARD19 →	+1.124	+0.363	.006	<.001	3	5
OESOPHAGUS	CAPZA2 →	+1.812	+0.377	.006	.003	3	5
LIVER	RAB8B →	+1.308	+0.376	.005	.003	3	5
OESOPHAGUS	PPARGC1B →	-0.883	-0.297	.001	<.001	3	5
OESOPHAGUS	TMBIM4 →	+0.750	+0.242	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901879 vs TGOLN2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →