Positive regulation of post-translational protein modification

Across TCGA patient cohorts, RNA activity of the Positive regulation of post-translational protein modification pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCAS1, COG1, and PACSIN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-translational protein modification activity versus BCAS1 in LUAD (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BCAS1 →	-0.942	-0.020	.002	.006	3	6
LUAD	COG1 →	-0.191	-0.029	.001	.001	3	6
UCEC	PACSIN2 →	-0.271	-0.039	<.001	.003	3	6
CCRCC	MLYCD →	-0.322	-0.023	.004	<.001	3	6
UCEC	FAM160B2 →	-0.247	-0.042	.001	.003	3	6
UCEC	LRBA_S2496 →	-0.255	-0.046	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901875 vs BCAS1 — LUAD

Explore this scatter interactively →