Positive regulation of post-translational protein modification

Across TCGA patient cohorts, RNA activity of the Positive regulation of post-translational protein modification pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS1, ART4, and MECR, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-translational protein modification activity versus IRS1 in OV (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRS1 →	-1.778	-0.188	.003	.008	3	2
COAD	ART4 →	-0.414	-0.897	.003	<.001	3	1
COAD	MECR →	-0.389	-0.647	.002	.008	3	1
COAD	TRIM6 →	-0.440	-0.835	.001	.002	3	1
COAD	GAD1 →	+1.123	+0.713	.001	.006	3	1
COAD	LGALS12 →	-0.654	-0.709	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901875 vs IRS1 — OV

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