Positive regulation of post-translational protein modification

Across TCGA cell cohorts, RNA activity of the Positive regulation of post-translational protein modification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECE1, BSDC1, and DNAJB2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-translational protein modification activity versus ECE1 in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ECE1 →	+2.029	+0.049	<.001	<.001	3	14
LARGE_INTESTINE	BSDC1 →	+0.826	+0.069	<.001	<.001	3	14
BONE	DNAJB2 →	+1.303	+0.059	.001	.005	1	15
LARGE_INTESTINE	KIAA1109 →	+0.849	+0.048	<.001	.001	3	13
BLOOD_Myeloma	HIVEP1 →	+1.109	+0.048	.005	.006	3	13
SOFT_TISSUE	HIVEP2 →	+1.508	+0.060	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901875 vs ECE1 — BLOOD_Leukemia

Explore this scatter interactively →