Negative regulation of post-translational protein modification

Across TCGA patient cohorts, RNA activity of the Negative regulation of post-translational protein modification pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, MAP1B_T1282, and MAP1B_S2211, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of post-translational protein modification activity versus MAP1B in LUAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAP1B →	+0.637	+0.031	.002	<.001	3	7
LSCC	MAP1B_T1282 →	+1.190	+0.024	.001	.006	3	7
HNSC	MAP1B_S2211 →	+0.581	+0.066	<.001	.005	3	6
UCEC	UCHL1 →	+1.317	+0.068	<.001	<.001	3	6
LUAD	ARFGAP3 →	-0.193	-0.031	.002	<.001	3	6
COAD	MAP1A →	+0.317	+0.021	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901874 vs MAP1B — LUAD

Explore this scatter interactively →